Publications on Cancer on the Theme of Tumour Destruction by Disrupting Energy Metabolism
Robert Jones MA PhD
Publications by Robert Jones on tumour destruction using Phenergan® to disrupt energy metabolism of cancer cells.
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Jones GRN. Cancer: restriction of chemical energy by fatty acids as the common pathway whereby various anti-tumour procedures selectively damage malignant cells in situ. Med Hypoth 1976; 2: 50-54.
Jones GRN. Cancer: energy uncoupling as a primary event in endotoxin-induced necrosis of the S180 sarcoma in situ. Biochem Soc Trans 1977; 5: 214-16.
Jones GRN. The selective induction of cellular damage within neoplasia in situ: a putative role for sympathomimetic agents. Med Hypoth 1976; 3: 215-16.
Jones GRN, Winter H, Merkel R. Alterations in the adenine nucleotide pattern as a sensitive means of assessing injury in a solid tumour. Hoppe-Seiler Zeits Physiol Chemie 1978; 359: 1102-103.
Jones GRN, Hummel J, Mahr J, Merkel R. Interference with energy production in the S180 sarcoma caused by isoproterenol and endotoxin. Naunyn-Schmiedeberg Arch Pharmacol 1979; 307 (Supplement): R18.
Jones GRN. Early mitochondrial damage in the induction of haemorrhagic necrosis in the Crocker sarcoma (S180) by endotoxin. J Cancer Res Clin Oncol 1979; 93: 245-54.
Jones GRN. Early cutback in chemical energy production in the Crocker sarcoma (S180) undergoing haemorrhagic necrosis as a result of endotoxin administration. J Cancer Res Clin Oncol 1980; 96: 53-64.
Jones GRN, Baum R, Merkel R, Schwarz M. Disturbance in vivo to energy production caused by hormones and sympathomimetics in the S180 sarcoma, with consequent drug-induced necrosis. Biochem Soc Trans 1980; 8: 105.
Jones GRN. Prevention of drug-induced upset to energy production in the S180 sarcoma by inhibition of prostaglandin synthetase. Biochem Soc Trans 1980; 8: 106-107.
Jones GRN, Ellis, R, Frohn MJN. Drug-induced interference with energy metabolism in the S180 sarcoma: a new principle in the production of selective tumour injury. Oncodev Biol Med 1981; 2: 155-64.
Jones GRN. A new approach to the selectivity of anti-tumour action. Brit J Cancer 1982; 45: 638.
Jones GRN, Miller S, Scobie-Trumper P. Resensitization of drug-resistant S180 tumour cells with ergotamine. Biochem Soc Trans 1982; 10: 502-503.
Jones GRN. Interference with energy production as a means of causing injury to a human pancreatic carcinoma. Oncology 1983; 40: 259-62.
Jones GRN, Frohn MJN. An injurious effect of chlorpromazine in the murine S180 sarcoma (var CB) and its relevance to cancer treatment. Biochem Soc Trans 1984; 12: 679-80.
Jones GRN, Frohn MJN, Beckett AH. Liminal therapy: a strategy for the complete and selective destruction of malignant tissue in situ. Med Hypoth 1984; 15: 349-59.
Jones GRN, Thatcher R. A comparison of the effects of the optical isomers of isoproterenol on energy metabolism in a mouse sarcoma. Experientia 1985; 41: 1045-46.
Jones GRN. Cancer therapy: phenothiazines in an unexpected role. Tumori 1985; 71: 563-69.
18. Jones GRN. Free radicals in immunological killing: the case for tumour necrosis factor (TNF). Med Hypoth 1986; 21: 267-71.
Jones GRN. Cancer therapy at the crossroads: which direction for the future? Physiol Chem Phys Med NMR 1991; 23: 217-20.
Jones GRN. Cancer destruction in vivo through disrupted energy metabolism. I. The endogenous mechanism of self-destruction within the malignant cell, and the roles of endotoxin, certain hormones and drugs, and active oxygen in causing cellular injury and death. Physiol Chem Phys Med NMR 1992; 24: 169-79.
Jones GRN. Cancer destruction in vivo through disrupted energy metabolism. II. Lipid peroxidation and cell death: drug resistance as a consequence of reversible cellular injury. Physiol Chem Phys Med NMR 1992; 24: 181-94.
Jones GRN. Cancer destruction in vivo through disrupted energy metabolism. III. Spontaneous drug resistance, selectivity of antineoplastic action, and strategies for intensifying tumour injury. Physiol Chem Phys Med NMR 1992; 24: 195-212.
Jones GRN. Successful cancer therapy with promethazine: the rationale. Med Hypoth 1996; 46: 25-29.
Jones GRN. Coagulative necrosis: the forgotten way to die. Biochem Soc Trans 1998; 26: S321.
Jones GRN. Treatment of cancer with low-dose phenothiazines, with special reference to promethazine. In: Non-Antibiotics: a new class of unrecognised antimicrobics (eds Chakrabarty AN, Molnar J, Dastidar SG) pp.79-93. Nat Sci Science Comm (NISCOM), New Delhi, India (1998).